• The John Radcliffe Hospital, Oxford
  • University Hospital Coventry
  • Platelets
  • Llandough Hospital, Cardiff
  • Achilles Tendon Tear
  • Achilles tendon rupture seen at sonography: discontinuity over several centimetres (red line)

The PATH-2 Study is a pragmatic multi-centre, blinded, randomised placebo-controlled trial comparing Platelet Rich Plasma injection (PRP) to placebo (imitation) injection in adults with Achilles tendon rupture (ATR). Two sub-studies are embedded within the main study to contribute to the understanding of the PRP mechanism in tendon healing.

The results indicate that PRP offers no benefit over standard care for acute Achilles tendon rupture.

Trial status

The PATH-2 Study is complete and results have been published in the BMJ.

The 2-year extended follow-up is also complete and was published in November 2022 in the Bone & Joint Journal.